Ketoconazole, Hydrocortisone, and GM-CSF in Treating Patients With Progressive Prostate Cancer After Hormone Therapy

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed adenocarcinoma of the prostate
• Progressive disease after androgen deprivation AND meets 1 of the following criteria:
• * Measurable disease
• * Measurable lesions ≥ 10 mm with spiral CT
• * Up to 5 lesions per organ and 10 lesions total should be identified as target lesions
• * No measurable disease
• * Patients with prostate-specific antigen (PSA)-only disease must have an elevated PSA
• * PSA evidence for progressive disease consists of a PSA level of ≥ 5 ng/mL that has risen on ≥ 2 successive occasions, ≥ 2 weeks apart
• * Patients with a positive bone scan must also have an elevated PSA
• Patients who received prior antiandrogen as a part of primary androgen ablation therapy must demonstrate disease progression after discontinuation of the antiandrogen
• * Disease progression after antiandrogen withdrawal is defined as 2 consecutive rising PSA values obtained ≥ 2 weeks apart, or documented osseous or soft tissue progression
• * Patients receiving flutamide must have had ≥ 1 of the PSA values obtained ≥ 4 weeks after flutamide discontinuation
• * Patients receiving bicalutamide or nilutamide must have had ≥ 1 of the PSA values obtained ≥ 6 weeks after antiandrogen discontinuation
• Testosterone \< 50 ng/dL
• PSA ≥ 5 ng/mL
• PATIENT CHARACTERISTICS:
• Karnofsky performance status 60-100%
• No serious intercurrent infections or nonmalignant uncontrolled medical illnesses
• No psychiatric illnesses OR social situations that would limit compliance
• No active or uncontrolled autoimmune disease
• ALT and AST normal
• Bilirubin normal
• Absolute neutrophil count ≥ 1,500/mm³
• Platelet count ≥ 100,000/mm³
• Creatinine ≤ 1.5 times upper limit or normal (ULN)
• Hemoglobin ≥ 8 g/dL
• No other currently active malignancy except for nonmelanoma skin cancer
• * No currently active malignancy defined as therapy completed with ≤ 30% risk of relapse
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• Patients must continue primary androgen deprivation therapy with a luteinizing-hormone releasing-hormone (LHRH) analogue if they have not undergone orchiectomy
• No prior systemic chemotherapy for prostate cancer
• * All other systemic chemotherapy must have been completed ≥ 2 years prior to study
• No other concurrent chemotherapy, immunotherapy, or radiotherapy
• Major surgery or radiation therapy completed ≥ 4 weeks prior to study
• No other concurrent corticosteroids, including routine use antiemetics
• No prior ketoconazole, aminoglutethimide, or corticosteroids for treatment of progressive prostate cancer
• No prior immunotherapy (e.g., vaccines or sargramostim GM-CSF)
• Patients receiving any other hormonal therapy (e.g., megestrol, finasteride, herbal product known to decrease PSA levels \[e.g., saw palmetto or PC-SPES\], or any systemic corticosteroid) must discontinue the agent ≥ 4 weeks prior to enrollment and progressive disease must be documented after discontinuation
• No initiation of bisphosphonate therapy within 1 month prior to starting study therapy
• * Patients on stable doses that show tumor progression are allowed to continue bisphosphonate
• No concurrent supplements or complementary medicines/botanicals, except any combination of the following:
• * Conventional multivitamin supplements
• * Selenium
• * Lycopene
• * Soy supplements
• * Vitamin E
• At least 8 weeks since prior radiopharmaceuticals (strontium chloride Sr 89, samarium Sm 153 lexidronam pentasodium)
• No other concurrent investigational or commercial anticancer agents or therapies