Patients with locally inoperable cancer, M1

Other preoperative tumor-specific radiotherapy, chemotherapy or endocrine treatment

Pregnancy or lactation

General contraindication against cytostatic treatment

T4 cancer; inflammatory disease, simultaneous or sequential bilateral breast cancer

Lacking compliance or understanding of disease

Serious concomitant disease

Second carcinoma or status post second carcinoma (except for treated squamous cell carcinoma of the skin or cervical carcinoma in situ)

Randomized Study Comparing Pre- and Postoperative vs. Conventional Adjuvant Treatment in Receptor-negative Patients