Premenopausal patients, non-determinable menopausal status

Previous radiotherapy, chemotherapy or endocrine treatment

Generalized disease (as verified by lung X-ray, skeletal X-ray, liver ultrasound)

Contraindications against tamoxifen or anastrozole

T4 tumors; carcinoma in situ

Lacking compliance or understanding of disease

Karnofsky Index \< 3

Serious concomitant disease

Septic complications, systemic infections or infectious local processes

Bilateral ovariectomy or ovarian irradiation

Second carcinoma or status post second carcinoma (except for treated squamous cell carcinoma of the skin or cervical carcinoma in situ)

Randomized Study Comparing Tamoxifen vs. Tamoxifen + Aminoglutethimide in Postmenopausal Receptor-positive Patients