2. Active hepatitis C or B

3. Active gout

4. Other active inflammatory diseases.

5. Active malignancy excluding basal or squamous cell carcinoma of the skin.

6. Gastrointestinal dysfunction requiring parental nutrition.

7. History of functional kidney transplant \< 6 months prior to study entry.

8. Anticipated live donor kidney transplant over study duration.

9. Prisoners, patients will significant mental illness, pregnant women, and other vulnerable populations.

10. Patients taking Vitamin E supplements \> 60 IU/day, vitamin C\> 500mg/day over the past 30days.

11. Patients taking anti-inflammatory medication except aspirin \< 325mg/day over the past 30 days.

12. Patient taking any prednisone therapy.

13. More than two hospitalizations within the last 90 days or one hospitalization within the last 30 days.

14. On experimental drug protocols.

15. Hypersensitivity to organic nitrates, isosorbide, or nitroglycerin.

16. Hypersensitivity to vitamin E or alpha lipoic acid.

17. Pregnant women

Tocopherols and Alpha Lipoic Acid Treatment Chronic Kidney Disease (TALAT)