Lead Sponsor

Mannkind Corporation

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Yes

•Clinical diagnosis of type 1 diabetes for at least 1 year
•Nonsmokers for prior 6 months
•BMI less than or equal to 35kg/m2
•HbA1c \> or = 7% and \< or = 11%
•Serum creatinine \< or = 1.8 mg/dL in female subjects and \< or = 2.0 mg/dL in male subjects
•FEV1 \> or = 70% of predicted, DLco \> or = 70% , TLC \> or = 80% predicted
•Maintenance of a treatment regimen of insulin less than or equal to 1.4 iu/kg/day
•Urine cotinine \< or = 100 ng/mL

•History of chronic obstructive pulmonary disease, asthma, any other clinically significant pulmonary disease confirmed by documented history, pulmonary function testing or radiologic findings
•Evidence of severe complications of diabetes
•Aminotransferase and/or alanine aminotransferase \> than 3 times the upper limit of normal