Effect of Diazoxide on the Obesity Secondary to Hypothalamic-pituitary Lesions

Inclusion Criteria

• •Age 6 to 18 years
• •Obesity with body mass index \> 97 percentile or \> 2 SD
• •Hypothalamic-pituitary lesions not evolutive
• •Hyperinsulinemia defined by insulin peak after oral glucose tolerance test\>100 UI/L
• •Absence of diabetes mellitus defined by basal plasma glucose \< 1.2 g/L and glucose peak after oral glucose tolerance test \< 2 g/L and HbA1c \< 7 %
• •Hormonal replacement therapy stable from at least three months excluding the treatment of diabetes insipidus which can be adjusted
• •Normal plasma thyroxine
• •Written informed consent of the children and the parents