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Safety and Immunogenicity of a Melan-A VLP Vaccine in Advanced Stage Melanoma Patients | Clinical Trials | Clareo Health

COMPLETEDPHASE2

Safety and Immunogenicity of a Melan-A VLP Vaccine in Advanced Stage Melanoma Patients

NCT00306553•Cytos Biotechnology AG

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate a specific cellular immune response in melanoma patients that have been vaccinated with a Melan-A VLP vaccine.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Able to provide written informed consent.
•Able and willing to complete all protocol requirements.
•Age: 18 years and older.
•Histological confirmed stage III or IV melanoma.
•At least one confirmed detectable target lesion
•HLA-A\*0201 haplotype
•Expected survival of at least 6 months.
•Full recovery from surgery.
•Able to undergo either CT scan or MRI scan for tumor assessment.
•Wash-out period of 4 weeks after chemotherapy
+3 more criteria

Exclusion Criteria

•Pregnant or nursing.
•Use of an investigational drug within 30 days before enrolment.
•Known or suspected brain metastases.
•Current use of an immunosuppressive drug or any concomitant medication that could potentially interfere with the study drug
•Presence of significant cardiovascular, renal, pulmonary, endocrine, infectious, neurological or bone marrow function disorders
•Serum tests positive for HIV, HBV, HCV.
•Active autoimmune diseases or severe allergies.
•Current diagnosis or history of relevant and severe psychiatric disorder that compromises the patient's ability to understand the patient information, to give informed consent, to comply with the trial protocol or to complete the study.
•Abuse of alcohol or other recreational drugs.
•Previous vaccination with a Melan-A analog peptide.

Locations (2)

Dept. of Dermatology, USZ

Zurich, Canton of Zurich, Switzerland

Dept. of Oncology, USZ

Zurich, Canton of Zurich, Switzerland

Key Dates

Last Updated

September 19, 2006

Conditions

Malignant Melanoma

Interventions

CYT004-MelQbG10

BIOLOGICAL

An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors

NCT07371663

Solid CancersNSCLC (Advanced Non-small Cell Lung Cancer)+3 more

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RECRUITINGPHASE1/PHASE2

Modified Vaccine for High Risk or Low Residual Melanoma Patients

NCT01898039

Malignant Melanoma

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 19, 2006Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Safety and Immunogenicity of a Melan-A VLP Vaccine in Advanced Stage Melanoma Patients

Inclusion Criteria

Exclusion Criteria

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