Lingjiang Li, MD, PhD

CONTACT

Liwen Tan, MD, PhD

CONTACT

Lead Sponsor

Central South University

Collaborators

Age

19 - 59 years

Sex

ALL

Healthy Volunteers

Yes

•Having at least one first-degree biological relative with schizophrenia and their age is between 19 and 59.
•Desire to participate in a medication trial.
•Is able to provide informed consent.
•Having moderate levels of negative symptoms, defined as 6 items rated 3 or higher on the Scale for the Assessment of Negative Symptoms (SANS).
•Scoring two or more standard deviations below normal in at least one of three cognitive domains: vigilance/working memory, long-term verbal memory, and executive functions.
•Scoring at least one standard deviation below normal in a second cognitive domain.

•IQ less than 80.
•Formal education less than 10 years.
•History of psychotic disorders.
•History of treatment with an antipsychotic medication.
•A substance abuse diagnosis within 6 months of diagnosis.
•A head injury with documented loss of consciousness exceeding 5 minutes (or subsequent cognitive deficits).
•A history of neurologic disease or damage.
•A medical condition with significant cognitive sequelae.
•A history of electroconvulsive treatment.