Having at least one first-degree biological relative with schizophrenia and their age is between 19 and 59.
Desire to participate in a medication trial.
Is able to provide informed consent.
Having moderate levels of negative symptoms, defined as 6 items rated 3 or higher on the Scale for the Assessment of Negative Symptoms (SANS).
Scoring two or more standard deviations below normal in at least one of three cognitive domains: vigilance/working memory, long-term verbal memory, and executive functions.
Scoring at least one standard deviation below normal in a second cognitive domain.
You may not be if
IQ less than 80.
Formal education less than 10 years.
History of psychotic disorders.
History of treatment with an antipsychotic medication.
A substance abuse diagnosis within 6 months of diagnosis.
A head injury with documented loss of consciousness exceeding 5 minutes (or subsequent cognitive deficits).
A history of neurologic disease or damage.
A medical condition with significant cognitive sequelae.
