Optimizing Pharmacotherapy for Bipolar Alcoholics

Exclusion Criteria

• •1\) Schizophrenia, schizoaffective and any nonbipolar psychotic disorder, unipolar major depression, primary anxiety disorder,mental retardation and signs of impaired cognitive functioning.
• •2\) Opiate dependence, abuse, or on opioid maintenance treatment for any reason and those with positive urine screen for opiate.
• •3)Current DSM-IV criteria for dependence on substances other that alcohol, cannabis,nicotine or caffeine.
• •4\) Neurological conditions including epilepsy, history of brain injury,encephalitis or any organic brain syndrome or documented focally abnormal EEG.
• •5)Medical conditions including severe cardiac, liver, kidney, endocrine, hematologic, or other impairing medical conditions, or impending surgery
• •6)Pregnancy
• •7)Inability or unwillingness to use contraceptive methods
• •8)Any medical condition or other reason that in the opinion of the investigator would prevent the subject from completing the protocol