Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Having a history of UC and more than 1 year from TPC/IPAA
Meet diagnostic criteria of IPS, i.e.
Symptoms of diarrhea and abdominal pain, with PDAI symptoms score \> (range 2-6).
Duration of symptoms \> 12 weeks in the preceding 12-months period
Pouch endoscopy shows no evidence of inflammation of the ileal pouch and rectal cuff
No antibiotic therapy, aspirin, or non-steriodal anti-inflammatory drugs for 2 weeks prior to entry into the study; no antidepressant and or anti-anxiety medicines for at least 4 weeks.
You may not be if
A history of development of side effects from amitriptyline
IPAA for FAP; celiac disease; chronic pouchitis; Crohn's disease; pouch stricture or anastomotic leak
Urinary retention, glaucoma, use of MAO inhibitors within past 14 days; acute recovery phase following myocardial infarction; pregnancy
Psychiatric disorder, including major depression, which requires medical therapy
