131 I-MIBG in Treating Patients With Refractory or Relapsed Neuroblastoma

You may be eligible if

• DISEASE CHARACTERISTICS:
• Original diagnosis of neuroblastoma based on 1 of the following criteria:
• * Histopathology
• * Elevated urine catecholamines with typical tumor cells in the bone marrow
• Refractory or relapsed disease, meeting 1 of the following criteria:
• * Failure to respond to standard therapy (e.g., combination chemotherapy with or without radiotherapy and surgery)
• * Evidence of disease progression (i.e., any new lesion or an increase in size of \> 25% of a pre-existing lesion) at any time
• Evaluable disease by MIBG scan within 6 weeks of study entry
• PATIENT CHARACTERISTICS:
• Not pregnant or nursing
• Fertile patients must use effective contraception
• Negative pregnancy test
• Bilirubin \< 2 times normal
• AST/ALT ≤ 10 times normal
• Creatinine ≤ 2 mg/dL
• Absolute neutrophil count\* ≥ 750/mm\^3 (transfusion independent)
• Platelet count\* ≥ 50,000/mm\^3 (20,000/mm\^3 if stem cells are available and platelet transfusion independent)
• Hemoglobin\* ≥ 10 g/dL (transfusion allowed)
• No dyspnea at rest
• No exercise intolerance
• No oxygen requirement
• No clinically significant cardiac dysfunction
• No disease of any major organ system that would preclude study compliance
• No active infection that meets grade 3 or 4 toxicity criteria NOTE: \*Patients with granulocytopenia and/or thrombocytopenia due to tumor metastases to the bone marrow may be eligible at the discretion of the principal investigator
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• Recovered from prior therapy
• At least 2 weeks since prior antitumor therapy
• At least 3 months since prior radiotherapy to any of the following fields:
• * Craniospinal
• * Total abdominal
• * Whole lung
• * Total body
• At least 1 day since prior cytokine therapy (e.g., filgrastim \[G-CSF\], sargramostim \[GM-CSF\], interleukin-6, or epoetin alfa)
• Prior iodine I 131 metaiodobenzylguanidine allowed provided it was given more than 6 months ago AND patient has adequate hematopoietic stem cells available
• No concurrent hemodialysis