Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
CTI BioPharma
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Histologically proven metastatic colorectal adenocarcinoma, failing one prior treatment containing oxaliplatin plus 5-FU/FA
At least one measurable lesion according to RECIST criteria for both Phase I and II
ECOG performance status 0 or 1
Adequate hematologic, renal and hepatic function
Wash out period of at least 4 weeks from surgery, 4 weeks from radiotherapy
You may not be if
Past or concurrent history of neoplasm other than colorectal adenocarcinoma, except curatively treated non melanoma skin cancer or in situ carcinoma of the cervix.
Pregnant or lactating patients
Prior treatment with camptothecins
Presence or history of CNS metastasis or carcinomatous leptomeningitis
Current active infection per investigator assessment
Unresolved bowel obstruction or partial obstruction, uncontrolled Crohn's disease or ulcerative colitis
Current history of chronic diarrhea greater than or equal to grade 1 (CTCAE version 3)
