Finding studies
Finding studies
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Lead
Johann Wolfgang Goethe University Hospital
* The study is an open-label, controlled, randomized single-center trial. * Patients post myocardial infarction (\>= 3 months) with a patent infarct-related artery are included. * Bone marrow-derived progenitor cells are aspirated under local anaesthesia, and after cell processing, are infused into the patent infarct-related artery during stop flow within the same day. Blood-derived progenitor cells are isolated out of 250ml peripheral venous blood, and after cell processing and 3 days culture, are infused into the patent infarct-related artery during stop flow. In addition, left ventricular angiography is performed. In the control group coronary angiography and left ventricular angiography without any intracoronary infusion are performed. * After 3 months, left ventricular angiography is repeated, and patients of the control group cross-over to active treatment with progenitor cells, whereas patients initially treated with progenitor cells cross-over to the alternate cell type. * The primary endpoint is the change in quantitative global left ventricular ejection fraction in LV angiography between the groups.
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
