Quantifying Abnormalities in Cortical Activation Associated With Auditory Hallucinations Using Functional Magnetic Resonance Imaging

The goal of the project is to characterize abnormalities in brain structure and function related to schizophrenia. We will use advanced magnetic resonance imaging (MRI) techniques to measure the degree and distribution of neuronal activity during specific cognitive tasks, alterations in neuronal connectivity, and how these are related to disease symptoms and treatment. We will focus on changes in brain structure and function associated with frequent auditory hallucinations, one of the most disabling manifestations of schizophrenia, and with neuroleptic treatment. In order to address these aims, we will study four groups of subjects: 1. patients who have frequent auditory hallucinations, 2. patients who are beginning a regimen of anti-psychotic medication, 3. patients who do not have frequent hallucinations and are not changing medication strategies, and 4. age-matched normal controls. Each group will contain 15 subjects for a total of 60.