Flushes and Sertraline Trial

Exclusion Criteria

• •History of bilateral oophorectomy
• •Breast or ovarian cancer
• •Liver disease
• •Kidney disease requiring dialysis
• •History of major depression (reported history of depression requiring therapy, hospitalization for depression, taking antidepressant drugs, history of suicide attempt)
• •History of bipolar affective disorder (reported history of bipolar disorder requiring therapy, medications, hospitalized for bipolar disorder)
• •Seizure disorder
• •History of hypersensitivity to sertraline or to SSRIs
• •Pregnancy or breast feeding
• •Any medical or psychiatric condition which, in the investigator's opinion, would preclude the participant from adhering to the protocol or completing the trial;
• •No estrogens or progestins for 3 months prior to screening or during enrollment
• •Selective estrogen receptor modulators (SERMS)
• •The following medications: clonidine, gabapentin, tricyclic antidepressants, monoamine oxidase (MAO) inhibitors, selective serotonin reuptake inhibitors (SSRIs), megesterol , oral contraceptives, androgens; and medications that are listed on the Pfizer Pharmaceutical drug insert as "contraindicated"