Signed Informed Consent

ErbB2(HER2)overexpressing breast cancer.

Brain lesion(s) which are progressing.

Prior treatment of brain metastases with Whole Brain Radiotherapy (WBR)and/or Stereotactic Radiosurgery (SRS).

Prior treatment with trastuzumab (Herceptin), either alone or in combination with chemotherapy.

Cardiac ejection fraction(LVEF)within the institutional range of normal as measured by Echocardiogram.

Able to swallow an oral medication.

Adequate kidney and liver function.

Adequate bone marrow function.

Lapatinib for Brain Metastases In ErbB2-Positive Breast Cancer