Pregnant, lactating, or planning to become pregnant.

Not ambulatory.

Participated in another trial with an investigational drug in the past 30 days.

Taking opioids for the management of drug addiction or cancer-related pain.

Severe constipation whereby the subject is at immediate risk of developing serious complications of constipation.

Gastrointestinal or pelvic disorders known to affect bowel transit, produce gastrointestinal (GI) obstruction, or contribute to bowel dysfunction.

HIV-infected, has active hepatitis, or has ever been infected with hepatitis C.

Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain