Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Sunnybrook Health Sciences Centre
With
American Health Assistance Foundation
Age
55–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
age \> 55 years
meet DSM-IV criteria for primary degenerative dementia
meet NINCDS-ARDA criteria for probable Alzheimer's Disease of at least one year's duration
mild to moderate cognitive impairment (Global Deterioration Scale GDS \<6, Mini-Mental State Examination \>10
on a stable dose of a cholinesterase inhibitor for at least 3 months
apathetic group only: Neuropsychiatric Inventory (NPI) Apathy subscale score \>=2
You may not be if
abnormal biochemical screening: blood cell count, vitamin B12, thyroid function tests, and syphilis screening tests
significant medical illness or other medical/neurological conditions which diminish cognitive function
evidence of seizure disorder
an Hachinski ischemic score \>3 indicating vascular dementia
a brain computed tomographic (CT) scan revealing focal lesions, or inconsistent with AD
electrocardiographic, laboratory or physical evidence of significant cardiovascular disease
presence of premorbid or current psychiatric diagnosis including: major depression, schizophrenia, psychotic symptoms of a severity likely to provoke violent or dangerous behaviour (i.e., command hallucinations to harm people or persecutory delusions that provoke violent reactions)
current or past psychoactive substance abuse or dependence (including alcohol, excluding nicotine)
contraindications to receiving dextroamphetamine or methylphenidate
have had administration of a depot neuroleptic injection within one treatment cycle of the first visit
