Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Sunesis Pharmaceuticals
Other objectives of this study are to assess the safety, tumor response, time to disease progression, survival rate and to explore several potential biomarkers to see how these levels change after administration of SNS-595.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Able to understand and willing to sign a written informed consent document
Patients who have recurrent or metastatic NSCLC, who have failed initial therapy with a platinum-containing regimen and have not received any second-line therapy (adjuvant therapy is acceptable if it was completed greater than or equal to 12 months before the cancer recurrence)
Measurable disease
Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1
Laboratory Values within the normal or reasonable reference range as specified by the protocol
You may not be if
Prior exposure to SNS-595
Pregnant or breastfeeding
Women of childbearing potential or male partners of women of childbearing potential unwilling to use an approved, effective means of contraception according to the institution's standards
Other active malignancies or other malignancies within the past 12 months except non-melanoma skin cancer, cervical intraepithelial neoplasia or prostatic intraepithelial neoplasia
Brain metastases, if present, without radiologic evidence of progressive disease for at least 3 months after completion of therapy
Myocardial infarction, cerebrovascular accident/transient ischemic attack (TIA) or thromboembolic event (deep vein thrombosis or pulmonary embolus) within 6 months before the first SNS-595 dose
Requires kidney dialysis (hemodialysis or peritoneal)
Prior chemotherapy, investigational agents, or radiation therapy within 28 days before Cycle 1 Day 0; however, nitrosoureas and mitomycin are not permitted for at least 42 days before Cycle 1 Day 0
In patients with toxicities caused by prior cancer therapy, those toxicities must have returned to less than or equal to Grade 1, with the exception of alopecia
Prior pelvic radiation therapy or radiation to greater than or equal to 25% of bone marrow reserve (prior palliative radiation is permitted as long as it does not exceed 25% of bone marrow reserve)
Any other medical, psychological, or social condition that, in the opinion of the Principal Investigator, would contraindicate the patient's participation in the clinical trial due to safety concerns or compliance with study procedures
