Rituximab, Temozolomide, and Methylprednisolone in Treating Patients With Recurrent Primary CNS Non-Hodgkin's Lymphoma

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed primary CNS non-Hodgkin's lymphoma by brain biopsy, positive cerebrospinal fluid cytology, or vitrectomy
• * Recurrent disease
• Measurable disease, define as bi-dimensionally measurable lesions with clearly defined margins by brain MRI or CT scan
• * Radiographical evidence of tumor progression by MRI or CT scan
• * Steroid therapy must be stable for 5 days prior to scan
• PATIENT CHARACTERISTICS:
• Age
• 18 and over
• Performance status
• Karnofsky 60-100%
• Life expectancy
• More than 8 weeks
• Hematopoietic
• WBC ≥ 3,000/mm\^3
• Absolute neutrophil count ≥ 1,500/mm\^3
• Platelet count ≥ 100,000/mm\^3
• Hemoglobin ≥ 10 g/dL (transfusion allowed)
• Hepatic
• SGOT \< 2 times upper limit of normal (ULN)
• Bilirubin \< 2 times ULN
• No active or latent hepatitis B infection
• Renal
• Creatinine \< 1.5 mg/dL OR
• Creatinine clearance ≥ 60 mL/min
• Other
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No other malignancy within the past 3 years except nonmelanoma skin cancer or carcinoma in situ of the cervix
• No uncontrolled significant medical illness that would preclude study treatment
• No active infection
• No active HIV infection
• No concurrent disease that would dangerously alter drug metabolism or obscure toxicity
• PRIOR CONCURRENT THERAPY:
• Biologic therapy
• At least 7 days since prior interferon or thalidomide
• No concurrent prophylactic filgrastim (G-CSF)
• No concurrent immunotherapy
• Chemotherapy
• No prior temozolomide
• At least 14 days since prior methotrexate
• At least 21 days since prior procarbazine
• At least 42 days since prior nitrosoureas
• No other concurrent chemotherapy
• Endocrine therapy
• See Disease Characteristics
• At least 7 days since prior tamoxifen
• No concurrent hormonal therapy
• Radiotherapy
• No concurrent radiotherapy
• Surgery
• Not specified
• Other
• Recovered from all prior therapy
• At least 28 days since prior investigational agents
• At least 28 days since other prior cytotoxic therapy
• At least 7 days since other prior non-cytotoxic agents (e.g., tretinoin) (radiosenitizers allowed)
• No other concurrent investigational drugs