Safety and Efficacy Study of Doxycycline in Combination With Interferon-B-1a to Treat Multiple Sclerosis

Exclusion Criteria

• •Medical or Psychiatric conditions that will affect patients ability to provide informed consent
• •inability to undergo MRI
• •clinically serious medical conditions or significantly abnormal labs
• •no use of these medications or procedures within six months prior to study:
• •\*monoclonal antibodies,total lymphoid radiation,systemic steroids,cytotoxic or immunosuppressive medications such as mitoxantrone or cyclophosphamide or any other investigational drugs
• •Interferon neutralizing antibody titers \>20
• •no breast feeding or pregnant
• •no patients with any systemic illness,psychiatric condition or other disorder that would concern safety of patient to complete procedures of protocol
• •abnormal blood test
• •clinically significant abnormality on chest x-ray (CXR)