Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
St. Jude Children's Research Hospital
Secondary objectives for this protocol include the following:
* To observe the degree of hematopoietic chimerism in T-cells during the first year posttransplant.
* To observe the relative proportions of donor/host T-regulatory cells during the first year posttransplant.
* To monitor rates of acute and chronic GVHD during the first year posttransplant.
Age
0–21
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
One of the following diagnoses:
Refractory severe aplastic anemia
Refractory Kostmann syndrome
Refractory Diamond-Blackfan anemia
Refractory amegakaryocytic thrombocytopenia
Absence of a suitable HLA-matched sibling donor and absence of a 10/10 allele matched unrelated donor.
Life expectancy of greater than six weeks as per the judgment of the principal investigator.
Karnofsky or Lansky Performance Status score of greater than or equal to 70%.
Creatinine clearance is greater than or equal to 40 cc/min/1.73 m2.
FVC greater than or equal to 40% of predicted or pulse oximetry greater than or equal to 92% on room air.
Does not have a known allergy to murine products.
You may not be if
Ejection fraction or shortening fraction below the lower limit of normal for age.
