Inoperable breast cancer

Patient unwilling to undergo surgery

Any reason why the patient may not be able to conform to study requirements

Any previous treatment for breast cancer

Previous Tamoxifen use as a part of breast cancer prevention trials

Not willing to stop taking drugs that affect sex-hormones such as HRT

Previous history of breast cancer

Previous history of invasive malignancy within the last 10 years

Any other severe disease that may prevent surgery, place the patient at risk, or influence the study results

Treatment with an experimental drug within the last 3 months

Risk of transmitting HIV, Hepatitis B or C

PROACT - Pre-Operative Arimidex Compared To Tamoxifen