Patients with \>2 concomitant oral anti-hyperglycaemic agents within 3 months of screening.

Previous exposure to a thiazolidinedione.

History of chronic insulin use.

Use of investigational drug within 30 days.

Systolic blood pressure (bp) \> 170 mmHg or diastolic bp \>100 mmHg.

Severe or unstable angina.

History of: gangrene, TIA, stroke, hepatic disease, alcohol or drug abuse, surgery of the carotid arteries or claustrophobia.

Rosiglitazone And Plaque Study for Type 2 Diabetes Mellitus