Standard High-Dose Alpha Interferon Versus Intermittent High-Dose Alpha Interferon

Exclusion Criteria

• •Confirmed distant metastasis
• •Choroid or mucosal melanoma
• •Pregnant or lactating women and women of childbearing potential not using a reliable form of contraception
• •Active autoimmun disease
• •patients with history of neuropsychiatric disease requiring hospitalization
• •Severe medical condition such us:
• •Florid hepatitis
• •Severe acute infection
• •Myocardial infarction within the past year,symptomatic angina pectoris
• •Grade III to IV congestive heart failure
• •serious pulmonary disease
• •HIV-positive patients with an AIDS - defining condition
• •treatment in another clinical drug trial within the last 30 days
• •A history of hypersensitivity to interferon alfa
• •History of maignant disease during the past 5 years (except for curatively treated skin carcinoma or in situ carcinoma)
• •Prior high dose interferon alfa therapy.Prior adjuvant low dose or intermediate-dose interferon alfa therapy is allowed