PTK787 in Patients With Advanced Metastatic Pancreatic Adenocarcinoma

Exclusion Criteria

• •Islet cell or neuroendocrine carcinomas of the pancreas.
• •History or presence of central nervous system disease.
• •Patients with a history of another primary malignancy \< 5 years
• •Prior chemo therapy \< 21 days prior to registration.
• •Prior biologic or immunotherapy \< 14 days prior to registration
• •Prior full field radiotherapy \< 28 days or limited field radiotherapy \< 14 days prior to registration.
• •Major surgery \< 28 days prior to registration.
• •Patients who have received investigational drugs \< 28 days prior to registration.
• •Prior therapy with anti-VEGF agents.
• •Pleural effusion or ascites that causes respiratory compromise.
• •Female patients who are pregnant or breast feeding.