Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National Institute on Drug Abuse (NIDA)
With
University of Texas
Cocaine is a strong central nervous system stimulant that is widely abused throughout the United Sates. Due to its widespread use, it is important to develop an effective treatment for cocaine dependence. Dopamine transporters (DAT) play an important role in the addictive nature of cocaine; the use of compounds that target DAT may be effective in treating cocaine dependent individuals. Research shows that GBR 12909 has a strong affinity for DAT. The purpose of this study is to determine the safety and potential interaction of GBR 12909 and cocaine in cocaine dependent individuals.
Age
18–45
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Meets DSM-IV criteria for current cocaine dependence
Not currently seeking treatment for cocaine dependence
Currently uses cocaine, as determined by a self-report and a positive urine test for cocaine, within 30 days prior to study entry
Within 20 % of ideal body weight, and weighs at least 100 lbs
Good general health
Normal electrocardiogram
Willing to use acceptable methods of contraception for the duration of the study
You may not be if
Current or history of a major psychiatric illness, other than drug dependence or disorders secondary to drug abuse
Meets DSM-IV criteria for dependence on any drugs other than cocaine, marijuana, nicotine, or alcohol
Physiologically dependent on alcohol and requires medical detoxification
Use of prescription drugs within 14 days prior to study entry
Use of non-prescription drugs within 7 days prior to study entry
If female, used an oral contraceptive, Depo-Provera, Norplant, or intrauterine progesterone contraceptive system, within 30 days prior to study entry
Pregnant or breastfeeding
History of liver disease
Current elevated aspartate aminotransferase or alanine aminotransferase levels
Donated a unit of blood within 4 weeks prior to study entry
Participated in any other clinical investigation within 4 weeks prior to study entry
History of any illness or behavior that, in the opinion of the investigator, might interfere with the study
Family history of early significant cardiovascular disease
Exhibits Hepatitis B surface antigen or Hepatitis C antibody
HIV infected
Syphilis
Active tuberculosis
Adult asthma
Chronic obstructive pulmonary disease
Unable to distinguish between 20 mg and 40 mg of intravenous cocaine
Clareo Health | Interaction Between Vanoxerine (GBR 12909) and Cocaine in Cocaine Dependent Individuals
