Interaction Between Vanoxerine (GBR 12909) and Cocaine in Cocaine Dependent Individuals

Exclusion Criteria

• •Current or history of a major psychiatric illness, other than drug dependence or disorders secondary to drug abuse
• •Meets DSM-IV criteria for dependence on any drugs other than cocaine, marijuana, nicotine, or alcohol
• •Physiologically dependent on alcohol and requires medical detoxification
• •Use of prescription drugs within 14 days prior to study entry
• •Use of non-prescription drugs within 7 days prior to study entry
• •If female, used an oral contraceptive, Depo-Provera, Norplant, or intrauterine progesterone contraceptive system, within 30 days prior to study entry
• •Pregnant or breastfeeding
• •History of liver disease
• •Current elevated aspartate aminotransferase or alanine aminotransferase levels
• •Donated a unit of blood within 4 weeks prior to study entry
• •Participated in any other clinical investigation within 4 weeks prior to study entry
• •History of any illness or behavior that, in the opinion of the investigator, might interfere with the study
• •Family history of early significant cardiovascular disease
• •Exhibits Hepatitis B surface antigen or Hepatitis C antibody
• •HIV infected
• •Syphilis
• •Active tuberculosis
• •Adult asthma
• •Chronic obstructive pulmonary disease
• •Unable to distinguish between 20 mg and 40 mg of intravenous cocaine