Aurograb and Vancomycin in MRSA Infection

Exclusion Criteria

• •Patients fulfilling the following criteria will not enter the study:
• •Prior Antibiotic Usage: Patients who have received (within 48 hours of study entry) a systemic anti-staphylococcal antibiotic other than vancomycin for longer than 24 hours, unless the patient was considered to have failed that regime ie a documented treatment failure (ie 3 days' treatment and not responding) or the Staphylococcus is resistant to the antibiotic in vitro (e.g. the patient is initially treated with flucloxacillin but the isolate subsequently identified as resistant) - in such cases the antibiotic must be changed to vancomycin to enter the study.
• •Concomitant Antibiotics: usage of concomitant antibiotic except as allowed by the protocol (see Section 5.3)
• •Patients with devices infected with S. aureus, including implants and catheters, which cannot be removed
• •Patients known to have AIDS, who have a CD4 cell count \< 200 cells/mm3
• •Patients with staphylococcal endocarditis, mediastinitis, meningitis, osteomyelitis and/or joint infections.
• •Asymptomatic carriers of MRSA - such patients must be clinically septic due to the MRSA
• •Patients with methicillin-sensitive CNS (MSSE)
• •Patients with methicillin-resistant CNS (MRSE) unless they are clinically significant blood culture isolates, as indicated by two blood cultures (taken from two different sites) growing the same CNS in a clinically septic patient in whom there is no other significant pathogen responsible for the sepsis
• •Females who have a positive pregnancy test
• •Patients who have a known allergy to any constituent of Aurograb® (i.e. hypersensitivity to antibody, nickel, urea or arginine)
• •Patients who have received an unlicensed drug within three months prior to the study
• •Patients with a concomitant medical condition, in whom, in the opinion of the Investigator, participation may create an unacceptable risk for the patient
• •Patients considered inappropriate for enrolment in this study by the Investigator for any other reason.