Functional Magnetic Resonance Imaging (fMRI) Studies in Pathological Gambling (PG) and Obsessive-Compulsive Disorder (OCD)

Exclusion Criteria

• •Subjects with a primary diagnosis of schizophrenia, personality disorder, or other psychotic disorders
• •Subjects with a primary diagnosis of an Axis I disorder that may require intervention
• •Must not score \>24 on the Montgomery-Asberg Depression Rating Scale (MADRS) (pathological gamblers only)
• •Subjects who live in a restrictive environment
• •Subjects with a current DSM-IV diagnosis of substance dependence or abuse, excluding nicotine
• •Subjects reporting a history of drug and/or alcohol dependence or abuse; subjects who report occasional drug use in the past will be discussed by a panel (consisting of Dr. Gilbert, Dr. Fan and Dr. Bartz), and will be considered for participation on a case by case basis
• •Subjects who have used psychotropic medications in the past week to six weeks (depending on the medication)
• •Subject has a positive drug urine screen
• •Female subjects who are pregnant
• •Subjects who report a history of severe liver, heart, or kidney disease because these conditions are associated with neurological sequella
• •Employees of the investigator or study center or their families
• •Finally, subjects who do not satisfy the following criteria will be excluded because they will be unable to undergo the MRI procedure. Specifically, subjects will be excluded who have:
• •1. a pacemaker
• •2. any implanted metallic chips in their head
• •3. ever worked around a metal lathe or had a shrapnel (war or gun shot) wound/injury
• •4. an implanted neuro-stimulatory or infusion/insulin pump
• •5. any devices placed in their blood vessels
• •6. any metal in/on their body
• •7. kidney disease
• •8. sickle-cell or hemolytic anemia
• •9. claustrophobia
• •10. any metallic tattoos
• •11. any body piercing that cannot be removed
• •12. dental braces
• •13. any permanent make-up
• •14. any cardiac stints