Assess Functional Outcomes in Anemic, Critically Ill, Trauma Patients When Taking Epoetin Alfa

Exclusion Criteria

• •Acute burns
• •Traumatic Brain Injury (TBI) with admission GCS \<= 12 and/or spinal cord injury
• •Cause of injury secondary to a fall from a standing position
• •Trauma victims transferred into the participating institution \> 8 hours post injury
• •Subjects not expected to survive 12 months given their injuries and/or pre-existing, uncorrectable medical condition
• •Chronic renal failure on dialysis
• •Significant hematological disease
• •All subjects expected to undergo chemotherapy during the course of treatment
• •A current diagnosis of uncontrolled hypertension
• •New onset seizures (within three months) or seizures not controlled by medication prior to admission
• •Gustillo III fracture, open pelvic fracture, traumatic amputation
• •Prior history or diagnosis of deep vein thrombosis (DVT), pulmonary embolism (PE), or genetic coagulation abnormality
• •Pregnancy or lactation
• •Refusal to accept blood transfusion
• •Received an experimental drug or used an experimental medical device within 30 days prior to the planned start of treatment
• •Treatment with any recombinant human erythropoietin within 30 days prior to enrollment - Known hypersensitivity to human albumin or mammalian cell-derived products or epoetin alfa
• •Employees of the investigator or study center with direct involvement in the proposed study or other studies under the direction of that investigator or study center