Salvage Therapy With Idarubicin in Relapsing CNS Lymphoma

Inclusion Criteria

• •Histological or cytological diagnosis of non-Hodgkin's lymphoma
• •Disease exclusively localised into the CNS at first diagnosis and failure
• •Progressive or recurrent disease
• •Previous treatment with HDMTX containing CHT and/or RT
• •Presence of at least one target lesion, bidimensionally measurable
• •Age 18 - 75 years
• •ECOG performance status \< 3 (Appendix 1).
• •No known HIV disease or immunodeficiency
• •HBsAg-negative and Ab anti-HCV-negative patients.
• •Adequate bone marrow function (plt \> 100000 mm3, Hb \> 9 g/dl, ANC \> 2.000 mm3)
• •Adequate renal function (serum creatinine \< 2 times UNL)
• •Adequate hepatic function (SGOT/SGPT \< 3 times UNL, bilirubin and alkaline phosphatase \< 2 times UNL)
• •Adequate cardiac function (VEF ≥ 50%)
• •Absence of any psycological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
• •Non-pregnant and non-lactating status for female patients. Adequate contraceptive measures during study participation for sexually active patients of childbearing potential.
• •No previous or concurrent malignancies at other sites with the exception of surgically cured carcinoma in-site of the cervix and basal or squamous cell carcinoma of the skin and of other neoplasms without evidence of disease since at least 5 years.
• •No concurrent treatment with other experimental drugs.
• •Informed consent signed by the patient before registration