Safety Study of Elidel (Pimecrolimus) 1% Cream to Treat Netherton Syndrome

Exclusion Criteria

• •Clinically significant physical examination or laboratory abnormalities
• •Clinical evidence of liver disease or liver injury as documented by abnormal liver function tests
• •Symptoms of a significant acute illness in the 30 week period preceding the start of treatment
• •Patients with known serious adverse reactions or hypersensitivity to macrolides or calcineurin inhibitors or with known hypersensitivity to any of the ingredients of the study medication or history of adverse reactions to the anesthetic product used for blood draws
• •Topical tacrolimus or Elidel within 2 weeks prior to dosing
• •Systemic steroid, systemic tacrolimus, or any immunosuppressant within 1 month prior to dosing
• •Phototherapy within 1 month prior to dosing
• •Use of inhibitors of Cytochrome P450 3A4 (CYP3A4) iso-enzyme within 2 weeks prior to dosing
• •Topical steroids or other topical therapy (except tacrolimus) may be used up to the day of 1st application of Elidel; however, treatment must be discontinued during the treatment period. Topical treatment of corticosteroids may resume immediately after the treatment period or in case an alert value has been exceeded and the Elidel treatment will be continued only on the face and neck.
• •Participation in any clinical trials within 2 months prior to dosing
• •History or clinical evidence of cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematologic, neurologic disease, or any disease other than Netherton syndrome, that may put the subject at undue risk. Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism or excretion of drugs.
• •History of presence of malignancy or lymphoproliferative disease
• •Presence of any viral or fungal or untreated bacterial skin infection
• •Known HIV positivity or active hepatitis B or C
• •History of immunocompromise
• •No vaccines containing live viruses are to be administered during the study period.