German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Exclusion Criteria

• •Severe leukemia associated complications, not controllable before therapy onset e.g.
• •life threatening infections as sepsis, pneumonia, hypoxia, shock, life threatening bleeding)
• •Severe comorbidity e.g.
• •decompensated renal failure if not caused by leukemia with Creatinine \> 2x ULN
• •heart failure (NYHA II/IV), instable Angina, significant coronary stenosis
• •hepatic insufficiency e.g. liver cirrhosis or chronic active hepatitis with bilirubin \> 1,5 x ULN and/or ASA, ALA, AP \> 2,5 ULN
• •decompensated metabolic disturbances (e.g. not controllable diabetes)
• •severe obstructive or restrictive pulmonary disease with hypoxaemia
• •Severe psychiatric illness or other circumstances which may compromise cooperation of the patient
• •Active second neoplasia
• •HIV infection
• •Severely reduced general condition
• •Cytostatic pre-treatment of ALL
• •Chemotherapy treatment of any other malignancy during the last 5 years
• •Participation in other clinical trials interfering with the study therapy