Tenofovir in HIV/HBV Coinfection

Exclusion Criteria

• •HCV-RNA positive or Anti-HAV IgM positive
• •Acute hepatitis (serum ALT \> 1000 U/L)
• •Active opportunistic infection
• •Other causes of chronic liver disease identified (autoimmune hepatitis, hemochromatosis, Wilsons disease, alfa-1-antitrypsin deficiency)
• •Concurrent malignancy requiring cytotoxic chemotherapy
• •Decompensated or Child's C cirrhosis
• •Alfa-fetoprotein (AFP) \> 3X ULN (unless negative CT scan or MRI within 3 months of entry date)
• •Pregnancy or lactation
• •Any other condition which in the opinion of the investigator might interfere with compliance or outcome of the study