Dose-finding Study to Evaluate Immunogenicity of Three Different Dose Levels of the IMVAMUNE (MVA-BN) Smallpox Vaccine.

Exclusion Criteria

• •Known or suspected history of smallpox vaccination or typical vaccinia scar.
• •Positive test result in MVA specific ELISA or PRNT at screening.
• •Positive result in HIV or HCV antibody test at screening.
• •HbsAG positive at screening.
• •Pregnancy or breast-feeding.
• •Uncontrolled serious infection i.e. not responding to antimicrobial therapy
• •History of any serious medical condition, which in the opinion of the investigator, would compromise the safety of the subject.
• •History of autoimmune disease
• •History of malignancy.
• •History of chronic alcohol abuse and/or intravenous drug abuse.
• •History of allergic disease or reactions likely to be exacerbated by any component of the vaccine.
• •History of anaphylaxis or severe allergic reaction.
• •Acute disease (a moderate or severe illness with or without a fever) at the time of enrolment.
• •Any vaccinations within a period starting 30 days prior to administration of the vaccine and ending at study conclusion.
• •Chronic administration of immuno-suppressants or other immune-modifying drugs.
• •Administration or planned administration of immunoglobulins and/or any blood products during the study period.
• •Use of any investigational or non-registered drug or vaccine.