UFT/LV Maintenance Vs Observation in Metastatic Breast Cancer Responsive to Chemotherapy

Exclusion Criteria

• •Metastatic breast cancer having received more than one chemotherapy line.
• •Tumor progression under chemotherapy
• •Free interval between primary tumor and metastases \> 5 years, with estrogen receptors and without visceral metastases
• •Free interval between primary tumor and metastases \< 18 months after adjuvant chemotherapy if first lime chemotherapy only led to a tumor stabilization
• •Concomitant hormonotherapy
• •Other cancer
• •Symptomatic brain metastases
• •Any uncontrolled severe disease except breast cancer (especially cardiac failure with LVEF \< 50% or coronary insufficiency
• •Psychiatric disorder
• •Other concomitant trial
• •Male patient
• •Pregnancy and breast-feeding (effective contraception is mandatory in the case of women of child-bearing potential)
• •History of high dose chemotherapy with bone marrow transplantation