Distant metastasis, Prior pelvic irradiation, Inflammatory bowel disease, Medical conditions which preclude radical therapy

History of malignancy within five years (except nonmelanoma skin cancer, CIN cervix)

Pregnancy

Hypersensitivity to celecoxib, NSAID, sulfonamides or 5-FU

Significant comorbid illness

History of peptic ulcer disease or NSAID-related gastrointestinal bleeding

Use of aspirin, other NSAID or coxib in the two weeks prior to study entry

Neutrophil count \<1.5x109/L, platelet count \<100x109/L, serum bilirubin \>1.25xULN (upper limit of normal), AST/ALT \>3xULN, serum creatinine \>1.25xULN

Celebrex With Preoperative Chemoradiation - Rectal Cancer

What this study is about