Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
St. Jude Children's Research Hospital
Age
0–21
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age \< 21 years
Diagnosis of severe aplastic anemia. (As defined by at least 2 of the following: ANC \< 500/μl, platelet count \< 20,000/μl, and a reticulocyte count \< 1% after correction for the hematocrit. In addition, the diagnostic bone marrow biopsy must contain less than 25% of the normal cellularity).
Patient must have failed one or more courses of immunosuppressive therapy that included ATG. As immunosuppression may take up to 6 months to demonstrate a response, patients must have been observed to have failed immunosuppression for a minimum of six months.
Absence of suitable HLA-matched sibling donor.
Negative serum pregnancy test for females with child bearing potential.
Patient/parent/guardian is able to provide informed consent.
You may not be if
Patients with a life expectancy \< 6 weeks.
Patients with severe renal disease (creatinine clearance \< 40cc/min/1.73m2)
Patients with pre-existing severe restrictive pulmonary disease (FVC \<40% of predicted)
Clareo Health | Purified CD34+ Hematopoietic Stem Cell Transplantation From Alternate Donors for Patients With Severe Aplastic Anemia
