Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma

You may be eligible if

• Eligibility Criteria:
• Initial clinical diagnosis of Retinoblastoma, with Bilateral tumors, OR Unilateral tumor with hope for salvage of vision AND Multiple primary tumors, or positive family history for retinoblastoma, or age \< 12 months
• No prior antitumor therapy (except enucleation of one eye)
• At least one tumor exceeds 6 mm in diameter
• No evidence of dissemination outside the globe
• Signed IRB-approved informed consent
• Patient/family available for follow-up