Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors

You may be eligible if

• Malignant Diseases:
• * Ewing's sarcoma/PNET:
• * CR1 - Metastatic disease at diagnosis, tumor volume \> 100 ml, pelvic bone primary
• * CR2 - Locally recurrent disease
• * Soft tissue sarcoma
• * CR1 - Metastatic disease at diagnosis or locally advanced disease where local control is suboptimal (i.e., inability to provide radiation therapy due to extent of disease).
• * CR2 - Locally recurrent disease (VGPR2 acceptable)
• * Hepatoblastoma:
• * VGPR1 - Patients with metastatic disease at diagnosis who have a persistently elevated alpha FP, or unresectable primary as a way of converting to resectable.
• * CR2/VGPR2
• * Hodgkin's Disease:
• * VGPR1 - Progression on primary therapy/Refractory disease
• * CR2/VGPR2
• * Germ Cell Tumor:
• * CR2/VGPR2 - recurrent disease
• * Wilms Tumor:
• * CR2/VGPR2 - recurrent disease
• IRB approved signed written informed consent by patient and/or their legally authorized guardian.
• Patients 21 years of age or younger at initial diagnosis, with older patients considered individually for primary pediatric disease diagnosis.
• Adequate central venous access (double lumen CVL or 2 single lumen PCVC).
• Adequate PBSC harvests with a minimum of 2.0 x 108 MNC/kg available for each PBSC rescue.
• Organ Function:
• * Platelets \> 50,000/ml
• * SGOT \< 10 x upper limits of normal
• * Creatinine \< 1.5 x normal baseline
• * Normal cardiac function in accordance with institutional policies
• * Normal pulmonary function in accordance with institutional policies.
• Physiologic status:
• * No active infections
• * Adequate performance status as measured by Karnofsky (\> 70%) or Lansky scale (\> 60%) as appropriate for age.
• Bone Marrow Status
• * No evidence of morphologic involvement with tumor at the time of transplant
• Off Study Criteria:
• Severe toxicity. Contact the Study Coordinator immediately and complete Adverse Reaction Form.
• Disease progression or relapse prior to PBSC #1 or between PBSC rescue # 1 and #2.
• Inability to collect adequate numbers of PBSC for successful transplantation.
• Patient or parent/guardian refusal to remain on study.