The main outcome measure used is the SANS (Scale for the Assessment of Negative Symptoms. This is a semi strucutured interview which provides scores from 0-70. This is administered at baseline, week 2, 3, 5 and 6.
Other outcome measures administered are (frequency mentioned above): PANSS (Positive and Negative Syndrome Scale) and the Calgery Depression Scale for Schizophrenia, A cognitive battery is also administered.
Inclusion Criteria:
* Diagnostic and Statistical Manual-IV diagnosis of schizophrenia or schizoaffective disorder, age over 18
* Persistent negative symptoms of moderate to severe intensity
* Failure to respond to a minimum of two antipsychotic medications
* No increase or initiation of new antipsychotic therapy in the four weeks prior to entering the trial Exclusion Criteria
* Prominent positive symptoms
* Have an unstable medical condition, neurological disorder or any history of seizure disorder or are currently pregnant or lactating
* Previous brain injury or surgery, any metal clips, plates or other metal items in the head, cardiac pacemaker
* Subjects at high risk of violence or suicide as determined by the investigator and treating clinicians
* Substance dependence
