Combination Chemotherapy, Radiation Therapy and Surgery for Esophageal Cancer

* Patients participating in this study must have a tumor biopsy taken to confirm the type of tumor. * Outpatient therapy with cetuximab alone will be given intravenously on week 0. * During week 1-8 outpatient radiation therapy will be started and continued once per day for 28 treatments or 5 1/2 weeks. * Outpatient chemotherapy (cisplatin, irinotecan and cetuximab) is given once per week on weeks 1, 2, 4, and 5. Cetuximab alone will be given on weeks 3, 6, 7, and 8. * A repeat CT scan and PET scan will be performed to restage the tumor on week 8. This is to confirm that the cancer has remained localized. * Inpatient surgery is scheduled 4 to 8 weeks after completion of chemotherapy and radiation therapy. * Cetuximab will be restarted within 4 weeks after surgery and continue weekly for 6 months. * During chemotherapy and radiation therapy, physical exams and vital signs will be performed before each chemotherapy treatment. Routine blood tests will also be performed. * Between chemotherapy-radiation therapy and surgery a CAT scan of chest, abdomen and pelvis along with a PET scan will be performed. * After surgery a CAT scan of chest, abdomen and pelvis will be performed every 3 months for 2 years then every 6 months for 3 years. An EGD (upper endoscopy) with biopsy will be done every 6 months for 2 years and then yearly for 3 years. Physical exam, vital signs and routine blood tests will be done every 2 weeks for 6 months, then every 3 months for 1.5 years, and then every 6 months for 3 years.