History of myocardial infarction (MI)

coronary angioplasty or bypass graft(s)

valvular disease or repair

unstable angina pectoris

transient ischemic attack (TIA), cerebrovascular attack, or cerebrovascular accident (CVA) within 6 months

Congestive heart failure NYHA Class III and IV

Uncontrolled hypertension

History of renal disease, peripheral vascular disease (PVD), pulmonary disease, gastrointestinal disease, active liver disease or endocrine disease

PPAR - Combination With Metformin