Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF).

Exclusion Criteria

• •Myocardial infarction in past 14 days
• •Clinical evidence of acute coronary syndrome causing worsening of HF,
• •Pregnant or breast-feeding,
• •Severe, uncorrected primary valvular disease, constrictive pericarditis, restrictive or hypertrophic cardiomyopathy,
• •Automated implanted cardiac defibrillator (AICD) or synchronization device implanted within the preceding 7 days,
• •Require mechanical ventilation, ultrafiltration, or hemodialysis at the time of enrollment,
• •Deterioration due to an acute or superimposed condition requiring therapy other than diuretics
• •Symptomatic ventricular tachycardia,
• •Severe concomitant primary hepatic disease,
• •Severe pulmonary disease,
• •Any other concomitant life-threatening disease,
• •CVA in the preceding 6 months,
• •Hypotension,
• •Participated in another clinical trial within 30 days,
• •Acute contrast nephropathy,
• •Admitted for heart transplant surgery or have had a heart transplant.