Oral Topotecan As A Radiosensitizing Agent In Rectal Cancer

Exclusion Criteria

• •A primary tumor totally excised.
• •Recurrent rectal cancer that failed initial treatment.
• •Exposure to topotecan, infection, immunodeficiencies, conditions of the gastrointestinal (GI) tract which would affect absorption, medication that maintains motility/gastric emptying.
• •Any concomitant malignancy within the last five years.
• •Severe medical problems unrelated to the malignancy which would limit compliance with the study.
• •Patients of child bearing potential.
• •Not practicing adequate contraception.
• •Patients who are pregnant or lactating.
• •Use of an investigational drug within 30 days or 5 half-lives of the first dose.