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A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies | Clinical Trials | Clareo Health

COMPLETEDPHASE4

A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies

NCT00154076•Eisai Korea Inc.

View on ClinicalTrials.gov

Summary

To assess the efficacy and safety of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies

Eligibility

Age

13 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Patients over 13 years old (complete the elementary school course).
•2. Patients had at least two seizures in the past and at least one seizure for the last 3 months before screening.
•3. Patients had no antiepileptic drugs for the last 4 months.
•4. Women of childbearing age who agree to contraception during participating this clinical trial.

Exclusion Criteria

•1. Pregnancy
•2. Patients who have progressive neurologic disease
•3. Allergy to sulfonamides
•4. Use of acetazolamide within a year
•5. Hemolytic anemia
•6. Patients who have abnormal liver function (GOT or GPT) values more than twice the normal values.
•7. Patients who have abnormal renal function (BUN or Creatinine) values more than three times the normal values.
•8. Patients who have history of drug or alcohol abuse.
•9. Glucose-6-phosphate dehydrogenase deficiency.
•10. Patients who were detected with renal stones on KUB (Kidney-Ureter-Bladder) test.
+4 more criteria

Locations (1)

Daegu Catholic University Medical Center

Daegu, South Korea

Key Dates

Start Date

September 1, 2005

Primary Completion Date

August 1, 2008

Completion Date

December 1, 2008

Last Updated

September 2, 2009

Enrollment

140

ESTIMATED participants

Conditions

Epilepsy

Interventions

Zonisamide

DRUG

Topiramate

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 2, 2009Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies

Inclusion Criteria

Exclusion Criteria

Thalamus Seizure Detection With a Deep Brain Stimulator System

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Intracranial Investigation of Neural Circuity Underlying Human Mood

Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment

AI-Based Mobile Intervention on Medication Non-Adherence and Transition

MEHMO Natural History and Biomarkers