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Lead
Chinese University of Hong Kong
With
Hong Kong Eye Hospital
Topiramate is approved for the treatment of epilepsy and prophylaxis of migraine attacks. There were case reports of acute angle closure glaucoma (AACG) associated with its use. AACG is particularly common in Asians because of a higher prevalence of narrow angle., we test the hypothesis whether topiramate narrows the angles which may render them more likely to suffer from AACG.
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Participants aged 18-75 with an indication for starting topiramate.
You may not be if
Patients with known allergy or intolerance to topiramate.
Recent exposure to topiramate (\<3 months).
Moderate to severe renal failure.
Known history of renal calculi or hepatic failure
Inability to give informed consent.
Pregnant women or women of child-bearing age who do not practise an acceptable means of contraception.
Patients known to have angle-closure glaucoma.
Clareo Health | Relationship Between Topiramate Use and Ocular Angle Status
