Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
St. Jude Children's Research Hospital
Secondary objectives for this protocol are to 1) assess the kinetics of lymphohematopoietic reconstitution and 2) describe the short and long-term (up to 5 years post- transplant) toxicity of haploidentical stem cell transplantation, including GVHD, in children with refractory hematological malignancies.
Age
2–21
Sex
ALL
Healthy volunteers
Not accepted
You may not be if
Acute myeloid leukemia (AML) \>25% blasts in bone marrow
Secondary AML
Myelodysplastic syndrome (MDS)
Secondary MDS
Chronic myeloid leukemia (CML)
Juvenile myelomonocytic leukemia (JMML)
Paroxysmal nocturnal hemoglobinuria (PNH)
Non-Hodgkin's lymphoma (NHL)\*
Hodgkin's Disease (HD)\*
\*Patients with lymphomas must have failed standard non-cross reactive combination salvage chemotherapy with or without radiation therapy followed by autologous stem cell transplant or patients with chemo resistant disease
If patient has had previous stem cell transplant, must not be no earlier than 3 months from previous date of transplant
Patients with shortening fraction greater than or equal to 25%
Patients with creatinine clearance greater than or equal to 40cc/min/1.73m\^2
Patients with FVC greater than or equal to 40% of predicted, or pulse oximetry greater than or equal to 92% on room air
Patients with a performance score (Lansky/Karnofsky) of greater than or equal to 50
Must have a suitable family member donor that is HIV negative, greater than or equal to 18 years of age available for stem cell donation
