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Keep this study
Lead
Boston Children's Hospital
With
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Charles H. Hood Foundation
This study will compare the physiological effects of two isoenergetic, nutrient-controlled diets that differ in glycemic index. The diets will be studied in obese male adults in a 10-day crossover feeding trial. Hypothesis: Obese subjects will show improvements in clinical endpoints associated with risk for diabetes and cardiovascular disease (CVD) after consuming a controlled low (compared to high) glycemic index diet for 10 days. 1º endpoint: insulin sensitivity as measured by the modified Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT). 2º endpoints: CVD risk factors; postprandial studies of oxidative stress; thermic effect of food.
Age
18–35
Sex
MALE
Healthy volunteers
Accepted
You may be eligible if
age 18 to 35 years
male
BMI ≥ 27 ≤45 kg/m2
willingness to refrain from alcohol and caffeinated beverage consumption for duration of study
You may not be if
major medical illness
an abnormal screening laboratory test
taking any prescription medications that might affect body weight
current smoking (1 cigarette during any of the last 7 days)
