Cyclophosphamide and Fludarabine Followed By an Autologous Lymphocyte Infusion and Interleukin-2 in Treating Patients With Refractory or Recurrent Metastatic Melanoma

You may be eligible if

• DISEASE CHARACTERISTICS:
• Diagnosis of melanoma
• * Metastatic disease
• Measurable disease
• HLA-A2 negative disease
• Disease did not respond to OR recurred after completion of prior high-dose interleukin-2 (IL-2)
• Eligible to receive high-dose IL-2
• No tumor reactive cells available for cell transfer therapy
• PATIENT CHARACTERISTICS:
• Age
• 18 and over
• Performance status
• ECOG 0-1
• Life expectancy
• At least 3 months
• Hematopoietic
• Absolute neutrophil count \> 1,000/mm\^3
• Platelet count \> 100,000/mm\^3
• Hemoglobin \> 8.0 g/dL
• No coagulation disorders
• Hepatic
• ALT and AST \< 3 times upper limit of normal
• Bilirubin ≤ 2.0 mg/dL (\< 3.0 mg/dL if due to Gilbert's syndrome)
• Hepatitis B surface antigen negative
• Hepatitis C antigen negative
• Renal
• Creatinine ≤ 2.0 mg/dL
• No renal failure requiring dialysis due to toxic effects of prior IL-2 administration
• Cardiovascular
• No myocardial infarction
• No cardiac arrhythmias
• No other major cardiovascular illness as evidenced by a positive stress thallium or comparable test
• Normal cardiac stress test (e.g., stress thallium, stress MUGA, dobutamine echocardiogram) AND LVEF ≥ 45% (for patients ≥ 50 years of age or who have a history of EKG abnormalities, symptoms of cardiac ischemia, or arrhythmias)
• Pulmonary
• No obstructive or restrictive pulmonary disease
• No other major respiratory illness
• FEV\_1 ≥ 60% of predicted (for patients with a prolonged history of cigarette smoking or symptoms of respiratory dysfunction)
• Immunologic
• HIV negative
• Epstein-Barr virus positive
• No active systemic infection
• No autoimmune disease (e.g., autoimmune colitis or Crohn's disease)
• No immunodeficiency due to prior chemotherapy or radiotherapy
• * Recovered immune competence after prior chemotherapy or radiotherapy as evidenced by normal lymphocyte count and WBC and an absence of opportunistic infection
• No other major immune system disease
• Other
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 4 months after completion of study treatment
• No other toxic effects during prior IL-2 administration that would preclude redosing with IL-2, including the following:
• * Mental status changes that would require intubation
• * Bowel perforation
• PRIOR CONCURRENT THERAPY:
• Biologic therapy
• See Disease Characteristics
• At least 4 weeks since prior systemic therapy
• Chemotherapy
• At least 6 weeks since prior nitrosoureas
• At least 4 weeks since prior systemic therapy
• Endocrine therapy
• No concurrent systemic steroid therapy
• Radiotherapy
• Not specified
• Surgery
• Not specified